Effect of Tyrosine Kinase Inhibitors on Renal Functions

Volume 1 - Issue 2

Özgür Can¹, Gülizar Manga Şahin², Umut Kasapoğlu³, Süleyman Baş⁴ and Bala Başak Öven Ustaalioğlu⁵

Received: June 26, 2018;   Published: July 02, 2018

DOI: 10.32474/JUNS.2018.01.000106

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Abstract

Background: We aim to document if any difference exists for renal functions between metastatic and non-metastatic patients.

Methods: The study population included 12 metastatic and 15 non-metastatic patients. Metastatic renal cancer patients using the TKIs were compared to non- metastatic patients.

Results: Preoperative estimated glomerular filtration rate (e-GFR) was significantly low in metastatic patients than nonmetastatic patients (p: 0.048). A trend toward increased acute kidney injury during hospital stay in the non-metastatic group was observed, but this fell just short of statistical significance (p: 0.109). Two groups did not differ significantly in terms of postoperative e-GFR (p: 0.256). No statistically significant differences were observed in actual e- GFR between two groups (p: 0.638). No statistically significant differences were found in pre-TKIs and post-TKIs e-GFR values (p: 0.735). Proteinuria was statistically more common in metastatic patients than non-metastatic patients (p<0.001). No statistically significant difference in age, sex, follow-up period, NSAIDs use, antihypertensive and ARBs/ACEIs use were documented between the two groups.

Conclusion: Increased risk for proteinuria was documented in metastatic patients with TKIs use. However, use of the TKIs had no effect on e- GFR. No statistically significant differences were observed in actual e- GFR between two groups.

Keywords: Hypertension; Glomerular Filtration Rate; Proteinuria; Tyrosine- Kinase Inhibitors

Abbrevations: RCC: Renal cell carcinoma ; TKIs: Tyrosine-Kinase Inhibitors; AKI: Acute Kidney Injury; NSAIDs: Non-Steroidal Anti-Inflammatory Drugs; ARBs: Angiotensin Receptor Blockers; ACEIs: Angiotensin Converting Enzyme Inhibitors; ARBs: Angiotensin Receptor Blockers; CCBs: Calcium Channel Blockers; e- GFR: Estimated Glomerular Filtration Rate

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