Investigation of Bladder Cancer, Breast Cancer,Colorectal Cancer, Endometrial Cancer, Kidney Cancer, Leukemia, Liver, Lung Cancer, Melanoma, Non-Hodgkin Lymphoma, Pancreatic Cancer, Prostate Cancer, Thyroid Cancer and Non-Melanoma Skin Cancer Using Synchrotron Technology For Proton Beam Therapy: An Experimental Biospectroscopic Comparative Study Volume 1 - Issue 1

Alireza Heidari*

• Faculty of Chemistry, California South University, USA

Received: February 22,2018;   Published: March 06,2018

*Corresponding author: Alireza Heidari, Faculty of Chemistry, California South University, USA

DOI: 10.32474/TRSD.2018.01.000102

Abstract PDF

Abbrevations: COSY: Correlation Spectroscopy; ECOSY: Exclusive Correlation Spectroscopy; TOCSY: Total Correlation Spectroscopy; INADEQUATE: Incredible Natural-Abundance Double-Quantum Transfer Experiment; HSQC: Heteronuclear Single-Quantum Correlation Spectroscopy; HMBC: Heteronuclear Multiple-Bond Correlation Spectroscopy; NOESY: Nuclear Overhauser Effect Spectroscopy; ROESY: Rotating Frame Nuclear Overhauser Effect Spectroscopy

Figure 1: Correlation Spectroscopy (COSY) analysis of malignant human cancer cells and tissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time.

In the current study, we have experimentally and comparatively investigated and compared malignant human cancer cells and tissues such as Bladder Cancer, Breast Cancer, Colorectal Cancer, Endometrial Cancer, Kidney Cancer, Leukemia, Liver, Lung Cancer, Melanoma, Non-Hodgkin Lymphoma, Pancreatic Cancer, Prostate Cancer, Thyroid Cancer and Non-Melanoma Skin Cancer before and after irradiating of synchrotron radiation for proton beam therapy using Correlation Spectroscopy (COSY), Exclusive Correlation Spectroscopy (ECOSY), Total Correlation Spectroscopy (TOCSY), Incredible Natural-Abundance Double-Quantum Transfer Experiment (INADEQUATE), Heteronuclear Single-Quantum Correlation Spectroscopy (HSQC), Heteronuclear Multiple-Bond Correlation Spectroscopy (HMBC), Nuclear Overhauser Effect Spectroscopy (NOESY) and Rotating Frame Nuclear Overhauser Effect Spectroscopy (ROESY). It is clear that malignant human cancer cells and tissues have gradually transformed to benign human cancer cells and tissues under synchrotron radiation with the passage of time (Figures 1-4) [1-50]. It should be noted that malignant human cancer cells and tissues were exposed under white synchrotron radiation for 30 days. Furthermore, there is a shift of the spectrum in all of spectra after irradiating of synchrotron radiation that it is because of the malignant human cancer cells and tissues shrink post white synchrotron irradiation with the passage of time. In addition, all of the figures are related to the same human cancer cells and tissues. Moreover, in all of the figures y-axis shows intensity and also x-axis shows energy (keV) [51-100].

Figure 2: Exclusive Correlation Spectroscopy (ECOSY) analysis of malignant human cancer cells and tissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time .

Figure 3: Total Correlation Spectroscopy (TOCSY) analysis of malignant human cancer cells and tissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time .

Figure 4: Incredible Natural-Abundance Double-Quantum Transfer Experiment (INADEQUATE) analysis of malignant human cancer cells and tissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time.

It can be concluded that malignant human cancer cells and tissues have gradually transformed to benign human cancer cells and tissues under synchrotron radiation with the passage of time (Figures 5-8). It should be noted that malignant human cancer cells and tissues were exposed under white synchrotron radiation for 30 days. Furthermore, there is a shift of the spectrum in all of spectra after irradiating of synchrotron radiation that it is because of the malignant human cancer cells and tissues shrink post white synchrotron irradiation with the passage of time. In addition, all of the figures are related to the same human cancer cells and tissues. Moreover, in all of the figures y-axis shows intensity and also x-axis shows energy (keV) [101-135].

Figure 5: Heteronuclear Single-Quantum Correlation Spectroscopy (HSQC) analysis of malignant human cancer cells and tissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time.

Figure 6: Heteronuclear Multiple-Bond Correlation Spectroscopy (HMBC) analysis of malignant human cancer cells and tissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time .

Figure 7: Nuclear Overhauser Effect Spectroscopy (NOESY) analysis of malignant human cancer cells and tissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time.

Figure 8: Rotating Frame Nuclear Overhauser Effect Spectroscopy (ROESY) analysis of malignant human cancer cells and tissues (a) before and (b) after irradiating of synchrotron radiation in transformation process to benign human cancer cells and tissues with the passage of time.

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93. Alireza Heidari (2017) A Comparative Computational and Experimental Study on Different Vibrational Biospectroscopy Methods, Techniques and Applications for Human Cancer Cells in Tumor Tissues Simulation, Modeling, Research, Diagnosis and Treatment. Open J Anal Bioanal Chem 1(1): 014-020.
94. Alireza Heidari (2017) Combination of DNA/RNA Ligands and Linear/ Non-Linear Visible-Synchrotron Radiation- Driven N-Doped Ordered Mesoporous Cadmium Oxide (CdO) Nanoparticles Photocatalysts Channels Resulted in an Interesting Synergistic Effect Enhancing Catalytic Anti-Cancer Activity. Enz Eng 6: 1.
95. Alireza Heidari (2017) Modern Approaches in Designing Ferritin, Ferritin Light Chain, Transferrin, Beta-2 Transferrin and Bacteriofer- ritin-Based Anti-Cancer Nano Drugs Encapsulating Nanosphere as DNA-Binding Proteins from Starved Cells (DPS). Mod Appro Drug Des 1(1).
96. Alireza Heidari (2017) Potency of Human Interferon ß-1a and Human Interferon ß-1b in Enzymotherapy, Immunotherapy, Chemotherapy, Ra-diotherapy, Hormone Therapy and Targeted Therapy of Encephalomyelitis Disseminate/Multiple Sclerosis (MS) and Hepatitis A, B, C, D, E, F and G Virus Enter and Targets Liver Cells. J Proteomics Enzymol 6: 1.
97. Alireza Heidari (2017) Transport Therapeutic Active Targeting of Human Brain Tumors Enable Anti-Cancer Nanodrugs Delivery across the Blood-Brain Barrier (BBB) to Treat Brain Diseases Using Nanoparticles and Nanocarriers under Synchrotron Radiation. J Pharm Pharmaceutics 4(2): 151-155.
98. Alireza Heidari, Christopher Brown (2017) Combinatorial Therapeutic Approaches to DNA/RNA and Benzylpenicillin (Penicillin G), Fluoxetine Hydrochloride (Prozac and Sarafem), Propofol (Diprivan), Acetylsali- cylic Acid (ASA) (Aspirin), Naproxen Sodium (Aleve and Naprosyn) and Dextromethamphetamine Nanocapsules with Surface Conjugated DNA/ RNA to Targeted Nano Drugs for Enhanced Anti-Cancer Efficacy and Targeted Cancer Therapy Using Nano Drugs Delivery Systems. Ann Adv Chem 1(2): 061-069.
99. Alireza Heidari (2016) Vibrational Spectroscopy of Nucleic Acids, Wahid Ali Khan (Editor), Basic Biochemistry, Austin Publishing Group (APG)/ Austin Publications LLC, New Jersey, USA 1-18.
100. Alireza Heidari (2017) High-Resolution Simulations of Human Brain Cancer Translational Nano Drugs Delivery Treatment Process under Synchrotron Radiation. J Transl Res 1(1): 1-3.
101. Alireza Heidari (2017) Investigation of Anti-Cancer Nano Drugs' Effects' Trend on Human Pancreas Cancer Cells and Tissues Prevention, Diagnosis and Treatment Process under Synchrotron and X-Ray Radiations with the Passage of Time Using Mathematica. Current Trends Anal Bioanal Chem 1(1): 36-41.
102. Alireza Heidari (2017) Pros and Cons Controversy on Molecular Imaging and Dynamics of Double-Standard DNA/RNA of Human Preserving Stem Cells-Binding Nano Molecules with Androgens/Anabolic Steroids (AAS) or Testosterone Derivatives through Tracking of Helium-4 Nucleus (Alpha Particle) Using Synchrotron Radiation. Arch Biotech- nol Biomed 1(1): 067-100.
103. Alireza Heidari (2017) Visualizing Metabolic Changes in Probing Human Cancer Cells and Tissues Metabolism Using Vivo ¹H or Proton NMR, ¹³C NMR, ¹⁵N NMR and ³¹P NMR Spectroscopy and Self-Organizing Maps under Synchrotron Radiation. SOJ Mater Sci Eng 5(2): 1-6.
104. Alireza Heidari (2017) Cavity Ring-Down Spectroscopy (CRDS), Circular Dichroism Spectroscopy, Cold Vapour Atomic Fluorescence Spectroscopy and Correlation Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation. Enliven: Challenges Cancer Detect Ther 4(2): e001.
105. Alireza Heidari (2017) Laser Spectroscopy, Laser-Induced Breakdown Spectroscopy and Laser-Induced Plasma Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation. Int J Hepatol Gastroenterol 3(4): 079-084.
106. Alireza Heidari (2017) Time-Resolved Spectroscopy and Time-Stretch Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation. Enliven: Pharmacovigilance and Drug Safety 4(2): e001.
107. Alireza Heidari (2017) Overview of the Role of Vitamins in Reducing Negative Effect of Decapeptyl (Triptorelin Acetate or Pamoate Salts) on Prostate Cancer Cells and Tissues in Prostate Cancer Treatment Process through Transformation of Malignant Prostate Tumors into Benign Prostate Tumors under Synchrotron Radiation. Open J Anal Bioanal Chem 1(1): 021-026.
108. Alireza Heidari (2017) Electron Phenomenological Spectroscopy, Electron Paramagnetic Resonance (EPR) Spectroscopy and Electron Spin Resonance (ESR) Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation. Austin J Anal Pharm Chem 4(3): 1091.
109. Alireza Heidari (2017) Therapeutic Nanomedicine Different High-Res- olution Experimental Images and Computational Simulations for Human Brain Cancer Cells and Tissues Using Nanocarriers Deliver DNA/ RNA to Brain Tumors under Synchrotron Radiation with the Passage of Time Using Mathematica and MATLAB. Madridge J Nano Tech. Sci 2 (2): 77-83.
110. Alireza Heidari (2017) A Consensus and Prospective Study on Restoring Cadmium Oxide (CdO) Nanoparticles Sensitivity in Recurrent Ovarian Cancer by Extending the Cadmium Oxide (CdO) Nanoparticles-Free Interval Using Synchrotron Radiation Therapy as Antibody-Drug Conjugate for the Treatment of Limited-Stage Small Cell Diverse Epithelial Cancers. Cancer Clin Res Rep 1(2): e001.
111. Alireza Heidari (2017) A Novel and Modern Experimental Imaging and Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under White Synchrotron Radiation. Cancer Sci Res Open Access 4(2): 1-8.
112. Alireza Heidari (2017) Different High-Resolution Simulations of Medical, Medicinal, Clinical, Pharmaceutical and Therapeutics Oncology of Human Breast Cancer Translational Nano Drugs Delivery Treatment Process under Synchrotron and X-Ray Radiations. J Oral Cancer Res 1(1): 12-18.
113. Alireza Heidari (2017) Vibrational Decihertz (dHz), Centihertz (cHz), Millihertz (mHz), Microhertz (^Hz), Nanohertz (nHz), Picohertz (pHz), Femtohertz (fHz), Attohertz (aHz), Zeptohertz (zHz) and Yoctohertz (yHz) Imaging and Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation. International Journal of Biomedicine 7(4): 335-340.
114. Alireza Heidari (2017) Force Spectroscopy and Fluorescence Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation. EC Cancer 2(5): 239-246.
115. Alireza Heidari (2017) Photoacoustic Spectroscopy, Photoemission Spectroscopy and Photothermal Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation. BAOJ Cancer Res Ther 3(4): 045-052.
116. Alireza Heidari (2017) J-Spectroscopy, Exchange Spectroscopy (EXSY), Nuclear Overhauser Effect Spectroscopy (NOESY) and Total Correlation Spectroscopy (TOCSY) Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation. EMS Eng Sci J 1(2): 006-013.
117. Alireza Heidari (2017) Neutron Spin Echo Spectroscopy and Spin Noise Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation. Int J Biopharm Sci 1: 103-107.
118. Alireza Heidari (2017) Vibrational Decahertz (daHz), Hectohertz (hHz), Kilohertz (kHz), Megahertz (MHz), Gigahertz (GHz), Terahertz (THz), Petahertz (PHz), Exahertz (EHz), Zettahertz (ZHz) and Yotta- hertz (YHz) Imaging and Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation. Madridge J Anal Sci Instrum 2(1): 41-46.
119. Alireza Heidari (2018) Two-Dimensional Infrared Correlation Spectroscopy, Linear Two-Dimensional Infrared Spectroscopy and Non-Linear Two-Dimensional Infrared Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation with the Passage of Time. J Mater Sci Nanotech- nol 6(1): 101.
120. Alireza Heidari (2018) Fourier Transform Infrared (FTIR) Spectroscopy, Near-Infrared Spectroscopy (NIRS) and Mid-Infrared Spectroscopy (MIRS) Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation with the Passage of Time. Int J Nanotechnol Nanomed 3(1): 1- 6.
121. Alireza Heidari (2018) Infrared Photo Dissociation Spectroscopy and Infrared Correlation Table Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation with the Passage of Time. Austin Pharmacol Pharm 3(1): 1011.
122. Alireza Heidari (2017) Novel and Transcendental Prevention, Diagnosis and Treatment Strategies for Investigation of Interaction among Human Blood Cancer Cells, Tissues, Tumors and Metastases with Synchrotron Radiation under Anti-Cancer Nano Drugs Delivery Efficacy Using MATLAB Modeling and Simulation. Madridge J Nov Drug Res 1(1): 18-24.
123. Alireza Heidari (2018) Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation, Open Access J Trans Med Res 2(1): 00026-00032.
124. Marcia Regina Risso Gobato, Ricardo Gobato, Alireza Heidari (2018) Planting of Jaboticaba Trees for Landscape Repair of Degraded Area. Landscape Architecture and Regional Planning 3(1): 1-9.
125. Alireza Heidari (2018) Fluorescence Spectroscopy, Phosphorescence Spectroscopy and Luminescence Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation with the Passage of Time. SM J Clin. Med. Imaging 4(1): 1018.
126. Alireza Heidari (2018) Nuclear Inelastic Scattering Spectroscopy (NISS) and Nuclear Inelastic Absorption Spectroscopy (NIAS) Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation. Int J Pharm Sci 2(1): 1-14.
127. Alireza Heidari (2018) X-Ray Diffraction (XRD), Powder X-Ray Diffraction (PXRD) and Energy-Dispersive X- Ray Diffraction (EDXRD) Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation. J Oncol Res 2(1): 1-14.
128. Alireza Heidari (2018) Correlation Two-Dimensional Nuclear Magnetic Resonance (NMR) (2D-NMR) (COSY) Imaging and Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation. EMS Can Sci 1: 1-001.
129. Alireza Heidari (2018) Thermal Spectroscopy, Photothermal Spectroscopy, Thermal Microspectroscopy, Photothermal Microspectroscopy, Thermal Macrospectroscopy and Photothermal Macrospectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation. SM J Biometrics Biostat 3(1): 1024.
130. Alireza Heidari (2018) A Modern and Comprehensive Experimental Biospectroscopic Comparative Study on Human Common Can- cers'Cells, Tissues and Tumors before and after Synchrotron Radiation Therapy. Open Acc J Oncol Med 1(1).
131. Alireza Heidari (2018) Heteronuclear Correlation Experiments such as Heteronuclear Single-Quantum Correlation Spectroscopy (HSQC), Heteronuclear Multiple-Quantum Correlation Spectroscopy (HMQC) and Heteronuclear Multiple-Bond Correlation Spectroscopy (HMBC) Comparative Study on Malignant and Benign Human Endocrinology and Thyroid Cancer Cells and Tissues under Synchrotron Radiation. J Endocrinol Thyroid Res 3(1): 555603.
132. Alireza Heidari (2018) Nuclear Resonance Vibrational Spectroscopy (NRVS), Nuclear Inelastic Scattering Spectroscopy (NISS), Nuclear Inelastic Absorption Spectroscopy (NIAS) and Nuclear Resonant Inelastic X-Ray Scattering Spectroscopy (NRIXSS) Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation. Int J Bioorg Chem Mol Biol 6(1e): 1-5.
133. Alireza Heidari (2018) A Novel and Modern Experimental Approach to Vibrational Circular Dichroism Spectroscopy and Video Spectroscopy Comparative Study on Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under White and Monochromatic Synchrotron Radiation. Glob J Endocrinol Metab 1 (3): 000514000519.
134. Alireza Heidari (2018) Pros and Cons Controversy on Heteronuclear Correlation Experiments such as Heteronuclear Single-Quantum Correlation Spectroscopy (HSQC), Heteronuclear Multiple-Quantum Correlation Spectroscopy (HMQC) and Heteronuclear Multiple-Bond Correlation Spectroscopy (HMBC) Comparative Study on Malignant and Benign Human Cancer Cells and Tissues under Synchrotron Radiation. EMS Pharma J 1(1): 002- 008.
135. Alireza Heidari (2018) A Modern Comparative and Comprehensive Experimental Biospectroscopic Study on Different Types of Infrared Spectroscopy of Malignant and Benign Human Cancer Cells and Tissues with the Passage of Time under Synchrotron Radiation. J Analyt Molecul Tech 3(1): 8.