Solvent Free Synthesis of Biscoumarins

Volume 2 - Issue 3

Mahesh Chand*

Received: March 22, 2018;   Published: April 03, 2018

DOI: 10.32474/AOICS.2018.02.000139

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Abstract

Coumarin and Coumarin-related compounds are major source of interest for many of medicinal chemist to explore its various pharmacological potentials especially bis-coumarin for their anticoagulant activity. A number of reports have appeared in the literature on the enhancement of bioactivity of bis heterocyclic compounds over simple heterocyclic compounds. Biscoumarin are very well known and possess better biological activities like anticoagulant, anti oxidant, antimicrobial activity, anti cancerous and analgesic activity than the parent nuclei. Hence, realizing the importance of biscoumarin, we thought to summarize the synthesis of bis-coumarins under solvent-free conditions in this review.

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