Preparation of Morphine Derivatives Using Ionic Liquids
Volume 3 - Issue 2
Sureshbabu Jayachandra, Madhuresh Kumar Sethi*, Sanjay Mahajan, Kunwar Sanjeev Singh, Bhairaiah Mara and
Purbita Chakraborty
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- Mylan Laboratories Ltd. ANRICH Industrial Estate, India
*Corresponding author:
Madhuresh Kumar Sethi, R and D, Mylan Laboratories Ltd, A ANRICH Industrial Estate, Bollaram, Sangareddy,
Telangana, India
Received: May 25, 2018; Published: June 11, 2018
DOI: 10.32474/AOICS.2018.03.000156
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Abstract
Dextromethorphan, an anti tussive drug belongs to the morphinan family, and is mostly available in the market as a combination
therapy. Most of the reported preparation procedures involve the use of racemic starting materials that give lower yields. (S)- Octa
base is one of the key starting raw materials used in our process and this easy, convenient and eco-friendly preparation (single
step) is reported in this manuscript. This drug, Dextromethorphan is produced in large volumes annually (> 150 tons/year). Most
reported synthetic procedures make use of huge amounts of volatile organic solvents which are hazardous for environment. This
will be a major issue in the near future. To overcome this problem, we have tried using Ionic liquid as a solvent in the preparation
and successfully arrived at best results, thereby decreasing the use of organic volatile solvents.
Keywords: Dextromethorphan, Morphine derivatives, Alkaloids, Formylation, Ionic liquid
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