Evaluation of Pregabaline Efficiency in Reducing Opioid
Use and Pain in Post-Operating Patients Subject to Total
Knee Arthroplasty Surgery
Volume 4 - Issue 5
Rogério Nascimento Costa1*, Laércio Pol Fachin2, Caio da Silva Ramos Leal3, Daniel Menezes Tenório Cavalcante4,
Lorena Fernandes Rosendo de Melo5, Pool Aníbal Alarcón León6 and Thalis Braga Batista7
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- 1Specialist in Orthopedics and Traumatology, Santa Casa de Misericórdia de Maceió, Brazil
- 2Post-doctorate in cellular and molecular biology, CESMAC University Center, Rua Cônego Machado, Brazil
- 3Post-doctorate in cellular and molecular biology, CESMAC University Center, Rua Cônego Machado, Brazil
- 4Resident Physician in Orthopedics and Traumatology, Santa Casa de Misericórdia de Maceió Address: Avenida Moreira e Silva, Brazil
- 5Anesthesiology Resident Physician, Santa Casa de Misericórdia de Maceió, Rua Prof. Sandoval Arroxelas,
- 6Resident Physician in Orthopedics and Traumatology, Hospital Santa Casa de Misericórdia de Maceió, Rua Jangadeiros Alagoanos, Brazil
- 7Medical student at CESMAC University Center, CESMAC University Center, Rua Rodolfo Abreu, Cruz das Almas, Brazil
*Corresponding author:
Rogério Nascimento Costa, Specialist in Orthopedics and Traumatology, Santa Casa de Misericórdia de
Maceió, Brazil.
Received: February 03, 2020; Published: February 18, 2020
DOI: 10.32474/RRHOAJ.2020.04.000198
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Abstract
Total knee arthroplasty (TKA) is a very efficient surgical process in the treatment of degenerative knee changes. However,
this procedure involves extensive tissue trauma, which contributes to the occurrence of severe postoperative pain. In this sense,
pregabalin seems to be effective when administered before surgery with significant pain reduction and consequently the amount
of opioid used postoperatively. Considering the importance of the subject and considering that there is no work in Alagoas and or
Northeast Brazilian populations that justifies the advantages of using Pregabalin in the preoperative period of TKA, this study aims
to gather information collected from patients operated at Santa Casa de Misericórdia de Maceió in a period of one year. Thirty-six
patients were studied during the research, where four were excluded due to data collection failure. The main indications for TKA
were 2 patients with rheumatoid arthritis, 16 with arthrosis and 13 with refractory pain. In this context, pregabalin has recognized
side effects, but in the study, it was observed safety in the administration of this drug in the patient group 24 hours before the
surgical procedure compared to the patient group 1 hour earlier as shown in Table 1. A greater reduction was observed. of pain
according to VAS pain 24 and 48 hours after surgery, in the pregabalin group 24 hours before, in relation to the others. No decrease in
postoperative opiod use was observed, as no study group achieved a VAS pain lower than 3 points over the length of stay. Therefore,
a larger study with larger patient samples and case-controls is needed to obtain significant results.
Keywords: Total knee arthroplasty; pregabalin;opioid; postoperative; Placebo
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