Effects of Circadian Rhythm Disorder on Learning
and Memory in Mice
Volume 2 - Issue 3
Huang Changquan* and Liu Qingxiu
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- The Third Hospital of Mianyang, China
*Corresponding author:
Huang Changquan, The third hospital of Mianyang, Sichuan 621000, China
Received: December 05, 2018; Published: December 13, 2018
DOI: 10.32474/OSMOAJ.2018.02.000137
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Abstract
Objective: The change of learning and memory was explored in circadian rhythm disorder mice induced by irregular light/
dark cycle.
Methods: Mice model of circadian rhythm disorder induced by irregular light/dark cycle. Twenty-four male ICR mice were
raised under different light/dark cycles including LD 12h/12h (Group 1: Normal circadian rhythm group), light 3h next to darkness
5h and light 5h next to dark 3h alternate every other day (Group 2: Circadian rhythm disorder group). The twenty-four ICR mice
were randomly assigned to these two groups and feed six months. Each group included twelve. Morris Water-maze task was used
as the judging criteria for spatial learning and memory.
Result: The learning and memory was significantly decreased in circadian rhythm disorder mice induced by irregular light/
dark cycle (P<0.05).
Conclusion: Circadian rhythm disorders impaired learning and memory.
Keywords: Circadian Rhythm; Light/Dark Cycle; Learning and Memory; Mice
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