Identification of Sirtuin Drug Targets (Homosapiens) For
Lung Cancer-Molecular Docking and ADME Analysis
Volume 3 - Issue 4
Sameer* and Sudhakar Malla
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- Department of Biotechnology, Indian Academy Degree College, Bangalore
*Corresponding author:
Sameer, Department of Biotechnology, Indian Academy Degree College, Bangalore
Received: April 25, 2020; Published: May 20, 2020
DOI: 10.32474/DDIPIJ.2020.03.000168
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Abstract
The objective of this study was to investigate the specific drug targets (Sirtuin 1,2,3,4,5, and 6) for lung cancer employing
molecular docking simulation and ADME analysis against Sinapaldehyde. The three-dimensional structure of the protein was
retrieved from Protein Data Base and of the ligand from Pubchem database. Molecular docking simulation of the compounds was
performed using Ligpep 2.3, Schrodinger Suite 2009. In the present study, drug likeness analysis was performed through Lipinski
filter & Admesar analysis using Swissadme online server and none of the compounds breached Lipinski’s and ADME parameters,
making them prominent agents for bio-activities. And the outcome represents the compounds (Sinapaldehyde) possibly serve as
for the cure of lung cancer.
Keywords: Sirtuin; Sinapaldehyde; Molecular docking; Lipinski; ADME Analysis, Anti-cancer
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